Srila Prabhupada explains the meaning of Srila Bhaktivinoda Thakura's song.
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"This is a song sung by Bhaktivinoda Thakura depicting the picture of the conditioned soul. Bhaktivinoda Thakura is presenting himself as one of the ordinary human beings, saying 'Due to my past fruitive activities, I have now fallen into this ocean of nescience, and I do not find any means of coming out of this great ocean.' Ei visaya-halahale: 'It is just like an ocean of poison.' If one takes some pungent food, it burns the heart. Similarly, although we are trying to be happy by sense enjoyment, actually our situation is becoming just the opposite, and the effort is causing our hearts to burn. And diva-nisi hiya jvale: 'That burning sensation is going on day and night, twenty-four hours a day.' Mana kabhu sukha nahi paya: 'And on account of this my mind is not at all satisfied.'"
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